AB1275 NEISSERIA GONORRHOEAE ARTHRITIS: A GROWING PROBLEM

Background Neisseria Gonorrhoeae infection (commonly gonococcus) have increased in recent years. Additionally, an increase the antibiotic-resistance of bacteria has been detected, including broad-spectrum cephalosporins, which could lead to untreatable complications like arthritis. Objectives The goal this study is describe gonococcal arthritis events identified a Rheumatology service between 2008 and 2022. Methods Retrospective longitudinal observational based on review medical records patients diagnosed with Department Doctor Peset University Hospital Valencia (Spain) since Sociodemographic clinical variables, antibiotic sensitivity profile therapy used were studied. Evolution infections also analyzed. Results Eight cases recorded period analyzed, all them years 2021-2022. All except one male. Half had sexual transmitted history, 75% syphilis infected 25% previous hepatitis B infection. most common form presentation was oligoarthritis. In three component tenosynovitis observed. Diagnostic arthrocentesis performed seven eight high profitability synovial fluid culture observed (only patient not isolated). showed cephalosporin azithromycin sensitivity, displayed favorable evolution (Table 1). Table 1. Antibiotic profile, treatment regimens administered duration treatment, need for surgery CASE ANTIBIOTIC SENSITIVITY PROFILE HOSPITAL TREATMENT OUTPATIENT NEED FOR SURGERY EVOLUTION 1 Ceftriaxone, cefotaxime, cefixime, gentamicin, azithromycin, doxycycline. Ceftriaxone (6 days). Cefixime (14 No. Resolution. 2 ceftazidime, ciprofloxacin, levofloxacin, azithromycin. Gentamicin + (Three Ciprofloxacin (10 3 (7 Azithromycin 4 Penicillin, ceftriaxone, aztreonam, rifampicin, chloramphenicol. Cloxacillin ceftriaxone (2 After (4 Amoxicillin-clavulanic acid (1 month). Yes (elbow arthrotomy debridement). 5 clindamycin, 6 Unrealized. Not hospitalized. cefixime (single dose). 7 cloxacillin doxycycline Intravenous by Home Hospitalization Unit (21 8 Patient refuses hospitalization. Levofloxacin Lost follow up. Conclusion An detected last two years, overlapping end social restrictions caused COVID-19 pandemic. Despite having described growing resistance, our profiles without isolating strains resistant cephalosporins or References [1]Barberá MJ, Serra-Pladevall J. Gonococcal infection: unresolved problem. Enferm Infecc Microbiol Clin (Engl Ed). 2019 Aug-Sep;37(7):458-466. doi: 10.1016/j.eimc.2018.12.008. [2]Unidad de vigilancia VIH, ITS y C. Vigilancia epidemiológica las infecciones transmisión sexual, 2019. Centro Nacional Epidemiología, Instituto Salud Carlos III/Plan sobre el Sida, Dirección General Pública; 2021. Acknowledgements Dr. Alida Taberner Cortés reviewing article. Disclosure Interests None Declared.